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Highly enantioselective alkyne additions to aldehydes in the presence of 1,1′-bi-2-naphthol and hexamethylphosphoramide

It is found that the addition of hexamethylphosphoramide to the solution of an alkyne, Et(2)Zn, and (S)-1,1′-bi-2-naphthol in methylene chloride allows the generation of an alkynylzinc at room temperature and shows highly enantioselective additions to aldehydes. The mild condition for the formation...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Gao, Ge, Xie, Ru-Gang, Pu, Lin
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397396/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15026570/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307136101
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