Aspirin-triggered 15-epi-lipoxin A(4) predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test

Inhibition of cyclooxygenase (COX)-2 increases cardiovascular deaths. Identifying a biomarker of COX-2 is desirable but difficult, since COX-1 and COX-2 ordinarily catalyze formation of an identical product, prostaglandin H(2). When acetylated by aspirin, however, COX-2 (but not COX-1) can form 15(R...

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Detalhes bibliográficos
Main Authors: Kirkby, Nicholas S., Chan, Melissa V., Lundberg, Martina H., Massey, Karen A., Edmands, William M. B., MacKenzie, Louise S., Holmes, Elaine, Nicolaou, Anna, Warner, Timothy D., Mitchell, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973905/
https://ncbi.nlm.nih.gov/pubmed/23792301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-215533
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