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KRAS(G12D)- and BRAF(V600E)-induced Transformation of Murine Pancreatic Epithelial Cells Requires MEK/ERK-stimulated IGF1R Signaling
Mutation of KRAS is a common initiating event in pancreatic ductal adenocarcinoma (PDAC). Yet, the specific roles of KRAS-stimulated signaling pathways in the transformation of pancreatic ductal epithelial cells (PDECs), putative cells of origin for PDAC, remain unclear. Here we demonstrate that KRA...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973739/ https://ncbi.nlm.nih.gov/pubmed/22871572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0340-T |
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