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Seeking Structural Specificity: Direct Modulation of Pentameric Ligand-Gated Ion Channels by Alcohols and General Anesthetics

Alcohols and other anesthetic agents dramatically alter neurologic function in a wide range of organisms, yet their molecular sites of action remain poorly characterized. Pentameric ligand-gated ion channels, long implicated in important direct effects of alcohol and anesthetic binding, have recentl...

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Detalles Bibliográficos
Main Authors: Howard, Rebecca J., Trudell, James R., Harris, R. Adron
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973611/
https://ncbi.nlm.nih.gov/pubmed/24515646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.113.007468
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