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The Toll-Like Receptor 4 Polymorphism Asp299Gly but Not Thr399Ile Influences TLR4 Signaling and Function

The common, co-segregating Toll-like receptor 4 (TLR4) non-synonymous single nucleotide polymorphisms (SNPs), Asp299Gly and Thr399Ile, are associated with hyporesponsiveness to inhaled lipopolysaccharide (LPS) and increased susceptibility to Gram negative pathogens in humans. The purpose of this stu...

詳細記述

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書誌詳細
主要な著者: Long, Huaicong, O'Connor, Brian P., Zemans, Rachel L., Zhou, Xiaofang, Yang, Ivana V., Schwartz, David A.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973565/
https://ncbi.nlm.nih.gov/pubmed/24695807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093550
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