The Toll-Like Receptor 4 Polymorphism Asp299Gly but Not Thr399Ile Influences TLR4 Signaling and Function

The common, co-segregating Toll-like receptor 4 (TLR4) non-synonymous single nucleotide polymorphisms (SNPs), Asp299Gly and Thr399Ile, are associated with hyporesponsiveness to inhaled lipopolysaccharide (LPS) and increased susceptibility to Gram negative pathogens in humans. The purpose of this stu...

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Bibliographic Details
Main Authors: Long, Huaicong, O'Connor, Brian P., Zemans, Rachel L., Zhou, Xiaofang, Yang, Ivana V., Schwartz, David A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973565/
https://ncbi.nlm.nih.gov/pubmed/24695807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093550
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