In vivo selection of basic region-leucine zipper proteins with altered DNA-binding specificities.
A transcription interference assay was used to generate mutant basic region-leucine zipper proteins with altered DNA-binding specificities. A library of mutants of a CCAAT/enhancer binding protein was constructed by randomizing five DNA-contacting amino acids in the basic region Asn-18, Ala-15, Val-...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1996
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39735/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8610143/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.7.2920 |
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