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The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling

The recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV), a betacoronavirus, is associated with severe pneumonia and renal failure. The environmental origin of MERS-CoV is as yet unknown; however, its genome sequence is closely related to those of two bat coronaviruses, named BtC...

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Detalhes bibliográficos
Main Authors: Matthews, Krystal L., Coleman, Christopher M., van der Meer, Yvonne, Snijder, Eric J., Frieman, Matthew B.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973478/
https://ncbi.nlm.nih.gov/pubmed/24443473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.062059-0
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