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Trehalose Glycopolymers as Excipients for Protein Stabilization

Herein, the synthesis of four different trehalose glycopolymers and investigation of their ability to stabilize proteins to heat and lyophilization stress are described. The disaccharide, α,α-trehalose, was modified with a styrenyl acetal, methacrylate acetal, styrenyl ether, or methacrylate moiety...

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Detalhes bibliográficos
Main Authors: Lee, Juneyoung, Lin, En-Wei, Lau, Uland Y., Hedrick, James L., Bat, Erhan, Maynard, Heather D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973403/
https://ncbi.nlm.nih.gov/pubmed/23777473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm4003046
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