Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes

Transfer of genetic information from genes into proteins is mediated by messenger RNA (mRNA) that must be first recruited to ribosomal pre-initiation complexes (PICs) by a mechanism that is still poorly understood. Recent studies showed that besides eIF4F and poly(A)-binding protein, eIF3 also plays...

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Bibliographic Details
Main Authors: Khoshnevis, Sohail, Gunišová, Stanislava, Vlčková, Vladislava, Kouba, Tomáš, Neumann, Piotr, Beznosková, Petra, Ficner, Ralf, Valášek, Leoš Shivaya
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973348/
https://ncbi.nlm.nih.gov/pubmed/24423867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1369
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