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Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2
NIR (novel INHAT repressor) can bind to p53 at promoters and inhibit p53-mediated gene transactivation by blocking histone acetylation carried out by p300/CBP. Like NIR, the E3 ubiquitin ligase MDM2 can also bind and inhibit p53 at promoters. Here, we present data indicating that NIR, which shuttles...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973334/ https://ncbi.nlm.nih.gov/pubmed/24413661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1371 |
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