Engineering of a conditional allele reveals multiple roles of XRN2 in Caenorhabditis elegans development and substrate specificity in microRNA turnover

Although XRN2 proteins are highly conserved eukaryotic 5′→3′ exonucleases, little is known about their function in animals. Here, we characterize Caenorhabditis elegans XRN2, which we find to be a broadly and constitutively expressed nuclear protein. An xrn-2 null mutation or loss of XRN2 catalytic...

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Detaylı Bibliyografya
Asıl Yazarlar: Miki, Takashi S., Rüegger, Stefan, Gaidatzis, Dimos, Stadler, Michael B., Großhans, Helge
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
RNA
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973323/
https://ncbi.nlm.nih.gov/pubmed/24445807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1418
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