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Length-dependent processing of telomeres in the absence of telomerase
In the absence of telomerase, telomeres progressively shorten with every round of DNA replication, leading to replicative senescence. In telomerase-deficient Saccharomyces cerevisiae, the shortest telomere triggers the onset of senescence by activating the DNA damage checkpoint and recruiting homolo...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973311/ https://ncbi.nlm.nih.gov/pubmed/24393774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1328 |
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