Tetrandrine blocks autophagic flux and induces apoptosis via energetic impairment in cancer cells

Lysosomes are acidic organelles that have a crucial role in degrading intracellular macromolecules and organelles during the final stage of autophagy. Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, was reported as an autophagy activator. Here, in contrast with previous studies, we show that Te...

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Главные авторы: Qiu, W, Su, M, Xie, F, Ai, J, Ren, Y, Zhang, J, Guan, R, He, W, Gong, Y, Guo, Y
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973245/
https://ncbi.nlm.nih.gov/pubmed/24625982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.84
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