Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people

Obesity is associated with chronic low-grade inflammation and oxidative stress that blunt insulin response in its target tissues, leading to insulin resistance (IR). IR is a characteristic feature of type 2 diabetes. Skeletal muscle is responsible for 75% of total insulin-dependent glucose uptake; c...

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Main Authors: Fabre, O, Breuker, C, Amouzou, C, Salehzada, T, Kitzmann, M, Mercier, J, Bisbal, C
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973244/
https://ncbi.nlm.nih.gov/pubmed/24651439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.104
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