Coordinated Silencing of Myc-Mediated miR-29 by HDAC3 and EZH2 As a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas

We investigated the transcriptional and epigenetic repression of miR-29 by Myc, HDAC3, and EZH2 in mantle cell lymphoma and other Myc-associated lymphomas. We demonstrate that miR-29 is repressed by Myc through a co-repressor complex with HDAC3 and EZH2. Myc contributes to EZH2 upregulation via repr...

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Detalhes bibliográficos
Main Authors: Zhang, Xinwei, Zhao, Xiaohong, Fiskus, Warren, Lin, Jianhong, Lwin, Tint, Rao, Rekha, Zhang, Yizhuo, Chan, John C, Fu, Kai, Marquez, Victor E., Chen-Kiang, Selina, Moscinski, Lynn C., Seto, Edward, Dalton, William S., Wright, Kenneth L., Sotomayor, Eduardo, Bhalla, Kapil, Tao, Jianguo
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973134/
https://ncbi.nlm.nih.gov/pubmed/23079660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.09.003
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