Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

In humans, exposure to aristolochic acid (AA) is associated with urothelial carcinoma of the upper urinary tract (UTUC). Exome sequencing of UTUCs from 19 individuals with documented exposure to AA revealed a remarkably large number of somatic mutations and an unusual mutational signature attributab...

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Bibliografiska uppgifter
Huvudupphovsmän: Hoang, Margaret L., Chen, Chung-Hsin, Sidorenko, Viktoriya S., He, Jian, Dickman, Kathleen G., Yun, Byeong Hwa, Moriya, Masaaki, Niknafs, Noushin, Douville, Christopher, Karchin, Rachel, Turesky, Robert J., Pu, Yeong-Shiau, Vogelstein, Bert, Papadopoulos, Nickolas, Grollman, Arthur P., Kinzler, Kenneth W., Rosenquist, Thomas A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973132/
https://ncbi.nlm.nih.gov/pubmed/23926200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006200
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