Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

In humans, exposure to aristolochic acid (AA) is associated with urothelial carcinoma of the upper urinary tract (UTUC). Exome sequencing of UTUCs from 19 individuals with documented exposure to AA revealed a remarkably large number of somatic mutations and an unusual mutational signature attributab...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hoang, Margaret L., Chen, Chung-Hsin, Sidorenko, Viktoriya S., He, Jian, Dickman, Kathleen G., Yun, Byeong Hwa, Moriya, Masaaki, Niknafs, Noushin, Douville, Christopher, Karchin, Rachel, Turesky, Robert J., Pu, Yeong-Shiau, Vogelstein, Bert, Papadopoulos, Nickolas, Grollman, Arthur P., Kinzler, Kenneth W., Rosenquist, Thomas A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973132/
https://ncbi.nlm.nih.gov/pubmed/23926200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006200
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