Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

In humans, exposure to aristolochic acid (AA) is associated with urothelial carcinoma of the upper urinary tract (UTUC). Exome sequencing of UTUCs from 19 individuals with documented exposure to AA revealed a remarkably large number of somatic mutations and an unusual mutational signature attributab...

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Main Authors: Hoang, Margaret L., Chen, Chung-Hsin, Sidorenko, Viktoriya S., He, Jian, Dickman, Kathleen G., Yun, Byeong Hwa, Moriya, Masaaki, Niknafs, Noushin, Douville, Christopher, Karchin, Rachel, Turesky, Robert J., Pu, Yeong-Shiau, Vogelstein, Bert, Papadopoulos, Nickolas, Grollman, Arthur P., Kinzler, Kenneth W., Rosenquist, Thomas A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973132/
https://ncbi.nlm.nih.gov/pubmed/23926200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006200
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