A common genetic variant within SCN10A modulates cardiac SCN5A expression

Variants in SCN10A, which encodes a voltage-gated sodium channel, are associated with alterations of cardiac conduction parameters and the cardiac rhythm disorder Brugada syndrome; however, it is unclear how SCN10A variants promote dysfunctional cardiac conduction. Here we showed by high-resolution...

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Bibliografski detalji
Glavni autori: van den Boogaard, Malou, Smemo, Scott, Burnicka-Turek, Ozanna, Arnolds, David E., van de Werken, Harmen J.G., Klous, Petra, McKean, David, Muehlschlegel, Jochen D., Moosmann, Julia, Toka, Okan, Yang, Xinan H., Koopmann, Tamara T., Adriaens, Michiel E., Bezzina, Connie R., de Laat, Wouter, Seidman, Christine, Seidman, J.G., Christoffels, Vincent M., Nobrega, Marcelo A., Barnett, Phil, Moskowitz, Ivan P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973109/
https://ncbi.nlm.nih.gov/pubmed/24642470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73140
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