A common genetic variant within SCN10A modulates cardiac SCN5A expression

Variants in SCN10A, which encodes a voltage-gated sodium channel, are associated with alterations of cardiac conduction parameters and the cardiac rhythm disorder Brugada syndrome; however, it is unclear how SCN10A variants promote dysfunctional cardiac conduction. Here we showed by high-resolution...

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Detalhes bibliográficos
Main Authors: van den Boogaard, Malou, Smemo, Scott, Burnicka-Turek, Ozanna, Arnolds, David E., van de Werken, Harmen J.G., Klous, Petra, McKean, David, Muehlschlegel, Jochen D., Moosmann, Julia, Toka, Okan, Yang, Xinan H., Koopmann, Tamara T., Adriaens, Michiel E., Bezzina, Connie R., de Laat, Wouter, Seidman, Christine, Seidman, J.G., Christoffels, Vincent M., Nobrega, Marcelo A., Barnett, Phil, Moskowitz, Ivan P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973109/
https://ncbi.nlm.nih.gov/pubmed/24642470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73140
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