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Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver.
The hepatic uptake rate for certain albumin-bound drugs and metabolites correlates poorly with their equilibrium unbound concentration in the plasma, suggesting that binding equilibrium may not always exist within the hepatic sinusoids. Currently available models for the uptake process assume bindin...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1985
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397305/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3856281/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.5.1563 |
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