The molecular origin of DNA-drug specificity in netropsin and distamycin.

X-ray analysis of the complex of netropsin with the B-DNA dodecamer of sequence C-G-C-G-A-A-T-T-BrC-G-C-G reveals that the antitumor antibiotic binds within the minor groove by displacing the water molecules of the spine of hydration. Netropsin amide NH furnish hydrogen bonds to bridge DNA adenine N...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kopka, M L, Yoon, C, Goodsell, D, Pjura, P, Dickerson, R E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1985
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397264/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2983343/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.5.1376
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