The molecular origin of DNA-drug specificity in netropsin and distamycin.

X-ray analysis of the complex of netropsin with the B-DNA dodecamer of sequence C-G-C-G-A-A-T-T-BrC-G-C-G reveals that the antitumor antibiotic binds within the minor groove by displacing the water molecules of the spine of hydration. Netropsin amide NH furnish hydrogen bonds to bridge DNA adenine N...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Kopka, M L, Yoon, C, Goodsell, D, Pjura, P, Dickerson, R E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1985
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397264/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2983343/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.5.1376
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