The molecular origin of DNA-drug specificity in netropsin and distamycin.

X-ray analysis of the complex of netropsin with the B-DNA dodecamer of sequence C-G-C-G-A-A-T-T-BrC-G-C-G reveals that the antitumor antibiotic binds within the minor groove by displacing the water molecules of the spine of hydration. Netropsin amide NH furnish hydrogen bonds to bridge DNA adenine N...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Kopka, M L, Yoon, C, Goodsell, D, Pjura, P, Dickerson, R E
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1985
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397264/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2983343/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.5.1376
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