TGF-β1 induces EMT reprogramming of porcine bladder urothelial cells into collagen producing fibroblasts-like cells in a Smad2/Smad3-dependent manner

Activation of fibroblasts and their differentiation into myofibroblasts, excessive collagen production and fibrosis occurs in a number of bladder diseases. Similarly, conversion of epithelial cells into mesenchymal cells (EMT) has been shown to increase fibroblasts like cells. TGF-β1 can induce the...

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Autors principals: Islam, Syed S., Mokhtari, Reza Bayat, El Hout, Yaser, Azadi, M. A., Alauddin, M., Yeger, Herman, Farhat, Walid A.
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2013
Matèries:
Regular Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972392/
https://ncbi.nlm.nih.gov/pubmed/24338442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-013-0216-4
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