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MicroRNA Let-7 Downregulates STAT3 Phosphorylation in Pancreatic Cancer Cells by Increasing SOCS3 Expression

Although dispensable for normal pancreatic function, STAT3 signaling is frequently activated in pancreatic cancers. Consistent downregulation of expression of microRNA let-7 is also characteristic of pancreatic ductal adenocarcinoma (PDAC) biopsy specimens. We demonstrate in this study that re-expre...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Patel, Kripa, Kollory, Anita, Takashima, Asami, Sarkar, Sibaji, Faller, Douglas V., Ghosh, Sajal K
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972339/
https://ncbi.nlm.nih.gov/pubmed/24491408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.01.020
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