MicroRNA Let-7 Downregulates STAT3 Phosphorylation in Pancreatic Cancer Cells by Increasing SOCS3 Expression

Although dispensable for normal pancreatic function, STAT3 signaling is frequently activated in pancreatic cancers. Consistent downregulation of expression of microRNA let-7 is also characteristic of pancreatic ductal adenocarcinoma (PDAC) biopsy specimens. We demonstrate in this study that re-expre...

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Autores principales: Patel, Kripa, Kollory, Anita, Takashima, Asami, Sarkar, Sibaji, Faller, Douglas V., Ghosh, Sajal K
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972339/
https://ncbi.nlm.nih.gov/pubmed/24491408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.01.020
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