Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma.

R24 is an IgG3 mouse monoclonal antibody that identifies GD3, a prominent ganglioside on the surface of melanoma cells and other cells of neuroectodermal origin. Twelve patients with metastatic melanoma were treated with R24 at three dose levels, 8, 80, or 240 mg/m2, over a period of 2 weeks. Peak a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Houghton, A N, Mintzer, D, Cordon-Cardo, C, Welt, S, Fliegel, B, Vadhan, S, Carswell, E, Melamed, M R, Oettgen, H F, Old, L J
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1985
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397231/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3883355/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.4.1242
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