Proteolysis of the Human DNA Polymerase Delta Smallest Subunit p12 by μ-Calpain in Calcium-Triggered Apoptotic HeLa Cells

Degradation of p12 subunit of human DNA polymerase delta (Pol δ) that results in an interconversion between Pol δ4 and Pol δ3 forms plays a significant role in response to replication stress or genotoxic agents triggered DNA damage. Also, the p12 is readily degraded by human calpain in vitro. Howeve...

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Main Authors: Fan, Xiaoting, Zhang, Qian, You, Chao, Qian, Yuanxia, Gao, Jing, Liu, Peng, Chen, Huiqing, Song, Huifang, Chen, Yan, Chen, Keping, Zhou, Yajing
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2014
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972206/
https://ncbi.nlm.nih.gov/pubmed/24691096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093642
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