Polμ Deficiency Increases Resistance to Oxidative Damage and Delays Liver Aging

Polμ is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polμ (Polμ(−/−)) show altered hematopoiesis homeostasis and DSB repair and a more pronounced nucleolytic resection of some V(D)J junctions. We previously showed that Polμ(−/−) mice have increased learn...

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Detalhes bibliográficos
Main Authors: Escudero, Beatriz, Lucas, Daniel, Albo, Carmen, Dhup, Suveera, Bacher, Jeff W., Sánchez-Muñoz, Aránzazu, Fernández, Margarita, Rivera-Torres, José, Carmona, Rosa M., Fuster, Encarnación, Carreiro, Candelas, Bernad, Raquel, González, Manuel A., Andrés, Vicente, Blanco, Luis, Roche, Enrique, Fabregat, Isabel, Samper, Enrique, Bernad, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972199/
https://ncbi.nlm.nih.gov/pubmed/24691161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093074
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