Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs

Recent progress in engineering the genomes of large animals has spurred increased interest in developing better animal models for diseases where current options are inadequate. Here, we report the creation of Yucatan miniature pigs with targeted disruptions of the low-density lipoprotein receptor (L...

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Detalles Bibliográficos
Main Authors: Davis, Bryan T., Wang, Xiao-Jun, Rohret, Judy A., Struzynski, Jason T., Merricks, Elizabeth P., Bellinger, Dwight A., Rohret, Frank A., Nichols, Timothy C., Rogers, Christopher S.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972179/
https://ncbi.nlm.nih.gov/pubmed/24691380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093457
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