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Implementation of TPMT testing
The activity of the enzyme thiopurine methyltransferase (TPMT) is regulated by a common genetic polymorphism. One in 300 individuals lack enzyme activity and 11% are heterozygous for a variant low activity allele and have an intermediate activity. The thiopurine drugs azathioprine, mercaptopurine an...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3971986/ https://ncbi.nlm.nih.gov/pubmed/23962279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12226 |
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