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Molecular Interactions between Mecamylamine Enantiomers and the Transmembrane Domain of the Human α4β2 Nicotinic Receptor
[Image: see text] To characterize the binding sites of mecamylamine enantiomers on the transmembrane domain (TMD) of human (h) (α4)(3)(β2)(2) and (α4)(2)(β2)(3) nicotinic acetylcholine receptors (AChRs), we used nuclear magnetic resonance (NMR), molecular docking, and radioligand binding approaches....
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical Society
2014
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3971955/ https://ncbi.nlm.nih.gov/pubmed/24437521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400969x |
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