Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving

Cue-induced cocaine craving is a major cause of relapse in abstinent addicts. In rats, cue-induced craving progressively intensifies (incubates) during withdrawal from extended-access cocaine self-administration. After ~1 month of withdrawal, incubated craving is mediated by Ca(2+)-permeable AMPARs...

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Main Authors: Loweth, Jessica A., Scheyer, Andrew F., Milovanovic, Mike, LaCrosse, Amber L., Flores-Barrera, Eden, Werner, Craig T., Li, Xuan, Ford, Kerstin A., Le, Tuan, Olive, M. Foster, Szumlinski, Karen K., Tseng, Kuei Y., Wolf, Marina E.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971923/
https://ncbi.nlm.nih.gov/pubmed/24270186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3590
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