Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia and ameliorates post-ischemic hippocampal dysfunction

BACKGROUND AND PURPOSE: Prohibitin (PHB) is a multi-functional protein involved in numerous cellular activities. PHB overexpression protects neurons from injury in vitro, but it is unclear whether PHB can protect selectively vulnerable hippocampal CA1 neurons in a clinically relevant injury model in...

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Autors principals: Kurinami, Hitomi, Shimamura, Munehisa, Ma, Tao, Qian, Liping, Koizumi, Kenzo, Park, Laibaik, Klann, Eric, Manfredi, Giovanni, Iadecola, Costantino, Zhou, Ping
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971834/
https://ncbi.nlm.nih.gov/pubmed/24619393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.113.003577
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