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The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding.

Specific DNA binding to the core consensus site GAGAGAG has been shown with an 82-residue peptide (residues 310-391) taken from the Drosophila transcription factor GAGA. Using a series of deletion mutants, it was demonstrated that the minimal domain required for specific binding (residues 310-372) i...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Pedone, P V, Ghirlando, R, Clore, G M, Gronenborn, A M, Felsenfeld, G, Omichinski, J G
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1996
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39717/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8610125/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.7.2822
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