Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis

The inhibition of triosephosphate isomerase (TPI) in glycolysis by the pyruvate kinase (PK) substrate phosphoenolpyruvate (PEP) results in a newly discovered feedback loop that counters oxidative stress in cancer and actively respiring cells. The mechanism underlying this inhibition is illuminated b...

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Bibliografiske detaljer
Main Authors: Grüning, Nana-Maria, Du, Dijun, Keller, Markus A., Luisi, Ben F., Ralser, Markus
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971408/
https://ncbi.nlm.nih.gov/pubmed/24598263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.130232
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