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Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Und...

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Bibliografische gegevens
Hoofdauteurs: Muller, Patricia A.J., Vousden, Karen H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970583/
https://ncbi.nlm.nih.gov/pubmed/24651012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.01.021
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