Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

The Tau protein is the major component of intracellular filaments observed in a number of neurodegenerative diseases known as tauopathies. The pathological mutant of Tau containing a proline-to-leucine mutation at position 301 (P301L) leads to severe human tauopathy. Here, we assess the impact of FK...

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Hauptverfasser: Giustiniani, Julien, Chambraud, Béatrice, Sardin, Elodie, Dounane, Omar, Guillemeau, Kevin, Nakatani, Hiroko, Paquet, Dominik, Kamah, Amina, Landrieu, Isabelle, Lippens, Guy, Baulieu, Etienne-Emile, Tawk, Marcel
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970538/
https://ncbi.nlm.nih.gov/pubmed/24623856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402645111
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