Non-random DNA fragmentation in next-generation sequencing

Next Generation Sequencing (NGS) technology is based on cutting DNA into small fragments, and their massive parallel sequencing. The multiple overlapping segments termed “reads” are assembled into a contiguous sequence. To reduce sequencing errors, every genome region should be sequenced several doz...

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Bibliografiske detaljer
Main Authors: Poptsova, Maria S., Il'icheva, Irina A., Nechipurenko, Dmitry Yu., Panchenko, Larisa A., Khodikov, Mingian V., Oparina, Nina Y., Polozov, Robert V., Nechipurenko, Yury D., Grokhovsky, Sergei L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970190/
https://ncbi.nlm.nih.gov/pubmed/24681819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04532
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