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Ankyrin-G Directly Binds to Kinesin-1 to Transport Voltage-Gated Na(+) Channels into Axons
Action potentials propagating along axons require the activation of voltage-gated Na(+) (Nav) channels. How Nav channels are transported into axons is unknown. Here we show KIF5/kinesin-1 directly binds to ankyrin-G (AnkG) to transport Nav channels into axons. KIF5 and Nav(1.2) channels bind to mult...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970081/ https://ncbi.nlm.nih.gov/pubmed/24412576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.11.023 |
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