FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance

FOXM1 is implicated in genotoxic drug resistance but its mechanism of action remains elusive. We show here that FOXM1-depletion can sensitize breast cancer cells and MEFs into entering epirubicin-induced senescence, with the loss of long-term cell proliferation ability, the accumulation of γH2AX foc...

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Hauptverfasser: Khongkow, Pasarat, Karunarathna, Upekha, Khongkow, Mattaka, Gong, Chun, Gomes, Ana R., Yagüe, Ernesto, Monteiro, Lara J., Kongsema, Mesayamas, Zona, Stefania, Man, Ellen P. S., Tsang, Janice W.-H., Coombes, R. Charles, Wu, Kou-Juey, Khoo, Ui-Soon, Medema, René H., Freire, Raimundo, Lam, Eric W.-F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969838/
https://ncbi.nlm.nih.gov/pubmed/24141789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.457
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