Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain.

According to the amyloid hypothesis for the pathogenesis of Alzheimer disease, beta-amyloid peptide (betaA) directly affects neurons, leading to neurodegeneration and tau phosphorylation. In rat hippocampal culture, betaA exposure activates tau protein kinase I/glycogen synthase kinase 3beta (TPKI/G...

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Detalhes bibliográficos
Main Authors: Hoshi, M, Takashima, A, Noguchi, K, Murayama, M, Sato, M, Kondo, S, Saitoh, Y, Ishiguro, K, Hoshino, T, Imahori, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC39697/
https://ncbi.nlm.nih.gov/pubmed/8610107
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