Application of Physiologically Based Absorption Modeling to Formulation Development of a Low Solubility, Low Permeability Weak Base: Mechanistic Investigation of Food Effect

Physiologically based pharmacokinetic (PBPK) modeling has been broadly used to facilitate drug development, hereby we developed a PBPK model to systematically investigate the underlying mechanisms of the observed positive food effect of compound X (cpd X) and to strategically explore the feasible ap...

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Main Authors: Zhang, Hefei, Xia, Binfeng, Sheng, Jennifer, Heimbach, Tycho, Lin, Tsu-Han, He, Handan, Wang, Yanfeng, Novick, Steven, Comfort, Ann
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969476/
https://ncbi.nlm.nih.gov/pubmed/24435225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-014-0075-1
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