Caffeine Inhibits the Activation of Hepatic Stellate Cells Induced by Acetaldehyde via Adenosine A2A Receptor Mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK Signal Pathway

Hepatic stellate cell (HSC) activation is an essential event during alcoholic liver fibrosis. Evidence suggests that adenosine aggravates liver fibrosis via the adenosine A2A receptor (A2AR). Caffeine, which is being widely consumed during daily life, inhibits the action of adenosine. In this study,...

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Detalhes bibliográficos
Main Authors: Wang, He, Guan, Wenjie, Yang, Wanzhi, Wang, Qi, Zhao, Han, Yang, Feng, Lv, Xiongwen, Li, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969328/
https://ncbi.nlm.nih.gov/pubmed/24682220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092482
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