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In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions
P-glycoprotein (P-gp) is an ATP (adenosine triphosphate)-binding cassette transporter that causes multidrug resistance of various chemotherapeutic substances by active efflux from mammalian cells. P-gp plays a pivotal role in limiting drug absorption and distribution in different organs, including t...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Dove Medical Press
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3969253/ https://ncbi.nlm.nih.gov/pubmed/24711707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/AABC.S56046 |
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