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Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity

BACKGROUND AND PURPOSE: While selective, bitter tasting, TAS2R agonists can relax agonist-contracted airway smooth muscle (ASM), their mechanism of action is unclear. However, ASM contraction is regulated by Ca(2+) signalling and Ca(2+) sensitivity. We have therefore investigated how the TAS2R10 ago...

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Detalhes bibliográficos
Main Authors: Tan, Xiahui, Sanderson, Michael J
Formato: Artigo
Idioma:Inglês
Publicado em: British Journal of Pharmacology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969078/
https://ncbi.nlm.nih.gov/pubmed/24117140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12460
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