A pan-BCL2 inhibitor renders bone marrow resident human leukemia stem cells sensitive to tyrosine kinase inhibition

Leukemia stem cells (LSC) play a pivotal role in chronic myeloid leukemia (CML) tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), in part, through alternative splicing of self-renewal and survival genes. To elucidate splice isoform regulators of human BC LSC maintenanc...

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Hoofdauteurs: Goff, Daniel J., Recart, Angela Court, Sadarangani, Anil, Chun, Hye-Jung, Barrett, Christian L., Krajewska, Maryla, Leu, Heather, Low-Marchelli, Janine, Ma, Wenxue, Shih, Alice Y., Wei, Jun, Zhai, Dayong, Geron, Ifat, Pu, Minya, Bao, Lei, Chuang, Ryan, Balaian, Larisa, Gotlib, Jason, Minden, Mark, Martinelli, Giovanni, Rusert, Jessica, Dao, Kim-Hien, Shazand, Kamran, Wentworth, Peggy, Smith, Kristen M., Jamieson, Christina A. M., Morris, Sheldon R., Messer, Karen, Goldstein, Lawrence S.B., Hudson, Thomas J., Marra, Marco, Frazer, Kelly A., Pellecchia, Maurizio, Reed, John C., Jamieson, Catriona H.M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968867/
https://ncbi.nlm.nih.gov/pubmed/23333150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.12.011
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