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Combined zinc supplementation with proinsulin C-peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis

Zinc is a trace element vital for immune function during host response to infection. The proinsulin C-peptide has been shown to exert beneficial effects through activation of the anti-inflammatory peroxisome proliferator activated receptor-γ (PPARγ) in experimental endotoxemia. Some in vitro activit...

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Bibliografiske detaljer
Main Authors: Slinko, Siarhei, Piraino, Giovanna, Hake, Paul W., Ledford, John R., O’Connor, Michael, Lahni, Patrick, Solan, Patrick D., Wong, Hector R., Zingarelli, Basilia
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968544/
https://ncbi.nlm.nih.gov/pubmed/24430544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000127
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