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Feasibility of Repairing Glomerular Basement Membrane Defects in Alport Syndrome

Alport syndrome is a hereditary glomerular disease that leads to kidney failure. It is caused by mutations affecting one of three chains of the collagen α3α4α5(IV) heterotrimer, which forms the major collagen IV network of the glomerular basement membrane (GBM). In the absence of the α3α4α5(IV) netw...

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Detalhes bibliográficos
Main Authors: Lin, Xiaobo, Suh, Jung Hee, Go, Gloriosa, Miner, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968506/
https://ncbi.nlm.nih.gov/pubmed/24262794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070798
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