The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat

The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed. After intravenous or oral digoxin dosing the arterial and hepatic portal vein (oral) AUC((0-24h)) were significantly reduced b...

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Bibliografiske detaljer
Main Authors: Lowes, Simon, Haslam, Iain S., Fihn, Britt-Marie, Hilgendorf, Constanze, Karlsson, Johan E., Simmons, Nicholas L., Ungell, Anna-Lena
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Diversity Preservation International 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968349/
https://ncbi.nlm.nih.gov/pubmed/27721343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics2010061
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