Endogenous IL-22 Plays a Dual Role in Arthritis: Regulation of Established Arthritis via IFN-γ Responses

OBJECTIVE: IL-22 is elevated in patients with inflammatory arthritis and correlates with disease activity. IL-22 deficient mice have reduced incidence of arthritis. Recombinant IL-22 restrains progression of arthritis via increase in IL-10 responses when administered prior to onset of arthritis. The...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Justa, Shivali, Zhou, Xiaoqun, Sarkar, Sujata
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968131/
https://ncbi.nlm.nih.gov/pubmed/24676270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093279
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